Downregulation of Fas activity rescues early onset of diabetes in c-Kit mice
نویسندگان
چکیده
Zhi-Chao Feng, Matthew Riopel, Jinming Li, Lisa Donnelly, and Rennian Wang Children’s Health Research Institute, London, Ontario, Canada; Departments of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; and Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
منابع مشابه
Downregulation of Fas activity rescues early onset of diabetes in c-Kit(Wv/+) mice.
c-Kit and its ligand stem cell factor (SCF) are important for β-cell survival and maturation; meanwhile, interactions between the Fas receptor (Fas) and Fas ligand are capable of triggering β-cell apoptosis. Disruption of c-Kit signaling leads to severe loss of β-cell mass and function with upregulation of Fas expression in c-Kit(Wv/+) mouse islets, suggesting that there is a critical balance b...
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